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Hypothalamic‐pituitary‐adrenal (HPA) axis suppression after treatment with glucocorticoid therapy for childhood acute lymphoblastic leukaemia

BACKGROUND: Glucocorticoids play a major role in the treatment of acute lymphoblastic leukaemia (ALL). However, supraphysiological doses can suppress the hypothalamic‐pituitary‐adrenal (HPA) axis. HPA axis suppression resulting in reduced cortisol response may cause an impaired stress response and a...

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Detalhes bibliográficos
Publicado no:Cochrane Database Syst Rev
Main Authors: Rensen, Niki, Gemke, Reinoud JBJ, van Dalen, Elvira C, Rotteveel, Joost, Kaspers, Gertjan JL
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley & Sons, Ltd 2017
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6486149/
https://ncbi.nlm.nih.gov/pubmed/29106702
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/14651858.CD008727.pub4
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