BMN 673, a novel and highly potent PARP1/2 inhibitor for the treatment of human cancers with DNA repair deficiency

PURPOSE: PARP1/2 inhibitors are a class of anticancer agents that target tumor-specific defects in DNA repair. Here, we describe BMN 673, a novel, highly potent PARP1/2 inhibitor with favorable metabolic stability, oral bioavailability and pharmacokinetic (PK) properties. EXPERIMENTAL DESIGN: Potenc...

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Publicado no:Clin Cancer Res
Main Authors: Shen, Yuqiao, Rehman, Farah L, Feng, Ying, Boshuizen, Julia, Bajrami, Ilirjana, Elliott, Richard, Wang, Bing, Lord, Christopher J., Post, Leonard E., Ashworth, Alan
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6485449/
https://ncbi.nlm.nih.gov/pubmed/23881923
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-13-1391
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