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BACE2, a conditional β-secretase, contributes to Alzheimer’s disease pathogenesis
Deposition of amyloid-β protein (Aβ) to form neuritic plaques is the characteristic neuropathology of Alzheimer’s disease (AD). Aβ is generated from amyloid precursor protein (APP) by β- and γ-secretase cleavages. BACE1 is the β-secretase and its inhibition induces severe side effects, whereas its h...
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| Publicado en: | JCI Insight |
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| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
American Society for Clinical Investigation
2019
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6485359/ https://ncbi.nlm.nih.gov/pubmed/30626751 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.123431 |
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