Measurement of Myofilament-Localized Calcium Dynamics in Adult Cardiomyocytes and the Effect of Hypertrophic Cardiomyopathy Mutations

RATIONALE: Subcellular Ca(2+) indicators have yet to be developed for the myofilament where disease mutation or small molecules may alter contractility through myofilament Ca(2+) sensitivity. Here, we develop and characterize genetically encoded Ca(2+) indicators restricted to the myofilament to dir...

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Bibliografske podrobnosti
izdano v:Circ Res
Main Authors: Sparrow, Alexander J., Sievert, Kolja, Patel, Suketu, Chang, Yu-Fen, Broyles, Connor N., Brook, Frances A., Watkins, Hugh, Geeves, Michael A., Redwood, Charles S., Robinson, Paul, Daniels, Matthew J.
Format: Artigo
Jezik:Inglês
Izdano: Lippincott Williams & Wilkins 2019
Teme:
Cellular Biology
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6485313/
https://ncbi.nlm.nih.gov/pubmed/30732532
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCRESAHA.118.314600
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