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Mavacamten rescues increased myofilament calcium sensitivity and dysregulation of Ca(2+) flux caused by thin filament hypertrophic cardiomyopathy mutations
Thin filament hypertrophic cardiomyopathy (HCM) mutations increase myofilament Ca(2+) sensitivity and alter Ca(2+) handling and buffering. The myosin inhibitor mavacamten reverses the increased contractility caused by HCM thick filament mutations, and we here test its effect on HCM thin filament mut...
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| Опубликовано в: : | Am J Physiol Heart Circ Physiol |
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| Главные авторы: | , , , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
American Physiological Society
2020
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7099453/ https://ncbi.nlm.nih.gov/pubmed/32083971 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpheart.00023.2020 |
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