Fn14 overcomes cisplatin resistance of high-grade serous ovarian cancer by promoting Mdm2-mediated p53-R248Q ubiquitination and degradation

BACKGROUND: High-grade serous ovarian cancer (HGSOC) is the most lethal of all gynecological malignancies. Patients often suffer from chemoresistance. Several studies have reported that Fn14 could regulate migration, invasion, and angiogenesis in cancer cells. However, its functional role in chemore...

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Bibliografiska uppgifter
I publikationen:J Exp Clin Cancer Res
Huvudupphovsmän: Wu, An-Yue, Gu, Li-Ying, Cang, Wei, Cheng, Meng-Xing, Wang, Wen-Jing, Di, Wen, Huang, Lei, Qiu, Li-Hua
Materialtyp: Artigo
Språk:Inglês
Publicerad: BioMed Central 2019
Ämnen:
Research
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC6485139/
https://ncbi.nlm.nih.gov/pubmed/31023317
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13046-019-1171-6
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