Expression Characteristics of Genes Hypermethylated and Downregulated in Rat Liver Specific to Nongenotoxic Hepatocarcinogens

This study examined hypermethylated and downregulated genes specific to carbon tetrachloride (CCl(4)) by Methyl-Seq analysis combined with expression microarray analysis in the liver of rats treated with CCl(4) or N-nitrosodiethylamine (DEN) for 28 days, by excluding those with DEN. Among 52 genes,...

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Udgivet i:Toxicol Sci
Main Authors: Ito, Yuko, Nakajima, Kota, Masubuchi, Yasunori, Kikuchi, Satomi, Saito, Fumiyo, Akahori, Yumi, Jin, Meilan, Yoshida, Toshinori, Shibutani, Makoto
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2019
Fag:
Evaluation of Genes Involved in Non-Genotoxic Carcinogenesis
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6484883/
https://ncbi.nlm.nih.gov/pubmed/30690589
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/toxsci/kfz027
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