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Ral Signals through a MAP4 Kinase-p38 MAP Kinase Cascade in C. elegans Cell Fate Patterning

C. elegans vulval precursor cell (VPC) fates are patterned by an epidermal growth factor (EGF) gradient. High-dose EGF induces 1o VPC fate, and lower dose EGF contributes to 2o fate in support of LIN-12/Notch. We previously showed that the EGF 2o-promoting signal is mediated by LET-60/ Ras switching...

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Detalhes bibliográficos
Publicado no:Cell Rep
Main Authors: Shin, Hanna, Kaplan, Rebecca E.W., Duong, Tam, Fakieh, Razan, Reiner, David J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6484852/
https://ncbi.nlm.nih.gov/pubmed/30184501
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2018.08.011
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