DMP1 prevents osteocyte alterations, FGF23 elevation and left ventricular hypertrophy in mice with chronic kidney disease

During chronic kidney disease (CKD), alterations in bone and mineral metabolism include increased production of the hormone fibroblast growth factor 23 (FGF23) that may contribute to cardiovascular mortality. The osteocyte protein dentin matrix protein 1 (DMP1) reduces FGF23 and enhances bone minera...

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Udgivet i:Bone Res
Main Authors: Dussold, Corey, Gerber, Claire, White, Samantha, Wang, Xueyan, Qi, Lixin, Francis, Connor, Capella, Maralee, Courbon, Guillaume, Wang, Jingya, Li, Chaoyuan, Feng, Jian Q., Isakova, Tamara, Wolf, Myles, David, Valentin, Martin, Aline
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6483996/
https://ncbi.nlm.nih.gov/pubmed/31044094
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41413-019-0051-1
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