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FGF23 directly inhibits osteoprogenitor differentiation in Dmp1-knockout mice

Fibroblast growth factor 23 (FGF23) is a phosphate-regulating (Pi-regulating) hormone produced by bone. Hereditary hypophosphatemic disorders are associated with FGF23 excess, impaired skeletal growth, and osteomalacia. Blocking FGF23 became an effective therapeutic strategy in X-linked hypophosphat...

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Principais autores: Guillaume Courbon, Dominik Kentrup, Jane Joy Thomas, Xueyan Wang, Hao-Hsuan Tsai, Jadeah Spindler, John Von Drasek, Laura Mazudie Ndjonko, Marta Martinez-Calle, Sana Lynch, Lauriane Hivert, Xiaofang Wang, Wenhan Chang, Jian Q. Feng, Valentin David, Aline Martin
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Clinical investigation 2023-12-01
Serier:JCI Insight
Fag:
Bone biology
Metabolism
Online adgang:https://doi.org/10.1172/jci.insight.156850
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