Bone proteins PHEX and DMP1 regulate fibroblastic growth factor Fgf23 expression in osteocytes through a common pathway involving FGF receptor (FGFR) signaling

Fibroblastic growth factor 23 (FGF23) is a circulating phosphaturic hormone. Inactivating mutations of the endopeptidase PHEX or the SIBLING protein DMP1 result in equivalent intrinsic bone mineralization defects and increased Fgf23 expression in osteocytes. The mechanisms whereby PHEX and DMP1 regu...

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Bibliographische Detailangaben
Hauptverfasser: Martin, Aline, Liu, Shiguang, David, Valentin, Li, Hua, Karydis, Anastasios, Feng, Jian Q., Quarles, L. Darryl
Format: Artigo
Sprache:Inglês
Veröffentlicht: Federation of American Societies for Experimental Biology 2011
Schlagworte:
Research Communications
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3136343/
https://ncbi.nlm.nih.gov/pubmed/21507898
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.10-177816
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