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Gene therapy prevents hepatic tumor initiation in murine glycogen storage disease type Ia at the tumor-developing stage
Hepatocellular adenoma/carcinoma (HCA/HCC) is a long-term complication of glycogen storage disease type-Ia (GSD-Ia) which is caused by a deficiency in glucose-6-phosphatase-α (G6Pase-α or G6PC), a key enzyme in gluconeogenesis. Currently, there is no therapy to address HCA/HCC in GSD-Ia. We have pre...
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| Publicado no: | J Inherit Metab Dis |
|---|---|
| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6483852/ https://ncbi.nlm.nih.gov/pubmed/30637773 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jimd.12056 |
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