Glycogen storage disease type Ia mice with less than 2% of normal hepatic glucose-6-phosphatase-α activity restored are at risk of developing hepatic tumors

Glycogen storage disease type Ia (GSD-Ia), characterized by impaired glucose homeostasis and chronic risk of hepatocellular adenoma (HCA) and carcinoma (HCC), is caused by a deficiency in glucose-6-phosphatase-α (G6Pase-α or G6PC). We have previously shown that G6pc−/− mice receiving gene transfer m...

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Vydáno v:Mol Genet Metab
Hlavní autoři: Kim, Goo-Young, Lee, Young Mok, Kwon, Joon Hyun, Cho, Jun-Ho, Pan, Chi-Jiunn, Starost, Matthew F., Mansfield, Brian C., Chou, Janice Y.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2017
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5346453/
https://ncbi.nlm.nih.gov/pubmed/28096054
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ymgme.2017.01.003
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