Downregulation of SIRT1 signaling underlies hepatic autophagy impairment in glycogen storage disease type Ia

A deficiency in glucose-6-phosphatase-α (G6Pase-α) in glycogen storage disease type Ia (GSD-Ia) leads to impaired glucose homeostasis and metabolic manifestations including hepatomegaly caused by increased glycogen and neutral fat accumulation. A recent report showed that G6Pase-α deficiency causes...

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Publicado en:PLoS Genet
Main Authors: Cho, Jun-Ho, Kim, Goo-Young, Pan, Chi-Jiunn, Anduaga, Javier, Choi, Eui-Ju, Mansfield, Brian C., Chou, Janice Y.
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science 2017
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5469511/
https://ncbi.nlm.nih.gov/pubmed/28558013
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1006819
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