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Downregulation of SIRT1 signaling underlies hepatic autophagy impairment in glycogen storage disease type Ia
A deficiency in glucose-6-phosphatase-α (G6Pase-α) in glycogen storage disease type Ia (GSD-Ia) leads to impaired glucose homeostasis and metabolic manifestations including hepatomegaly caused by increased glycogen and neutral fat accumulation. A recent report showed that G6Pase-α deficiency causes...
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| Publicado no: | PLoS Genet |
|---|---|
| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Public Library of Science
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5469511/ https://ncbi.nlm.nih.gov/pubmed/28558013 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1006819 |
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