Inhibiting myeloid-derived suppressor cell trafficking enhances T cell immunotherapy

Recruitment of myeloid-derived suppressor cells (MDSCs) into tumors induces local immunosuppression in carcinomas. Here, we assessed whether SX-682, an orally bioavailable small-molecule inhibitor of CXCR1 and CXCR2, could block tumor MDSC recruitment and enhance T cell activation and antitumor immu...

Descripció completa

Guardat en:
Dades bibliogràfiques
Publicat a:JCI Insight
Autors principals: Sun, Lillian, Clavijo, Paul E., Robbins, Yvette, Patel, Priya, Friedman, Jay, Greene, Sarah, Das, Rita, Silvin, Chris, Van Waes, Carter, Horn, Lucas A., Schlom, Jeffrey, Palena, Claudia, Maeda, Dean, Zebala, John, Allen, Clint T.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Clinical Investigation 2019
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6483637/
https://ncbi.nlm.nih.gov/pubmed/30944253
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.126853
Etiquetes: Afegir etiqueta
Sense etiquetes, Sigues el primer a etiquetar aquest registre!

Ítems similars