Inhibiting myeloid-derived suppressor cell trafficking enhances T cell immunotherapy

Recruitment of myeloid-derived suppressor cells (MDSCs) into tumors induces local immunosuppression in carcinomas. Here, we assessed whether SX-682, an orally bioavailable small-molecule inhibitor of CXCR1 and CXCR2, could block tumor MDSC recruitment and enhance T cell activation and antitumor immu...

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Bibliografiske detaljer
Udgivet i:JCI Insight
Main Authors: Sun, Lillian, Clavijo, Paul E., Robbins, Yvette, Patel, Priya, Friedman, Jay, Greene, Sarah, Das, Rita, Silvin, Chris, Van Waes, Carter, Horn, Lucas A., Schlom, Jeffrey, Palena, Claudia, Maeda, Dean, Zebala, John, Allen, Clint T.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Clinical Investigation 2019
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6483637/
https://ncbi.nlm.nih.gov/pubmed/30944253
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.126853
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