Mature neutrophils suppress T cell immunity in ovarian cancer microenvironment

Epithelial ovarian cancer (EOC) often presents with metastases and ascites. Granulocytic myeloid–derived suppressor cells are an immature population that impairs antitumor immunity. Since suppressive granulocytes in the ascites of patients with newly diagnosed EOC were morphologically mature, we hyp...

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Udgivet i:JCI Insight
Main Authors: Singel, Kelly L., Emmons, Tiffany R., Khan, ANM Nazmul H., Mayor, Paul C., Shen, Shichen, Wong, Jerry T., Morrell, Kayla, Eng, Kevin H., Mark, Jaron, Bankert, Richard B., Matsuzaki, Junko, Koya, Richard C., Blom, Anna M., McLeish, Kenneth R., Qu, Jun, Ram, Sanjay, Moysich, Kirsten B., Abrams, Scott I., Odunsi, Kunle, Zsiros, Emese, Segal, Brahm H.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Clinical Investigation 2019
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6483507/
https://ncbi.nlm.nih.gov/pubmed/30730851
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.122311
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