Mature neutrophils suppress T cell immunity in ovarian cancer microenvironment

Epithelial ovarian cancer (EOC) often presents with metastases and ascites. Granulocytic myeloid–derived suppressor cells are an immature population that impairs antitumor immunity. Since suppressive granulocytes in the ascites of patients with newly diagnosed EOC were morphologically mature, we hyp...

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Detalhes bibliográficos
Publicado no:JCI Insight
Main Authors: Singel, Kelly L., Emmons, Tiffany R., Khan, ANM Nazmul H., Mayor, Paul C., Shen, Shichen, Wong, Jerry T., Morrell, Kayla, Eng, Kevin H., Mark, Jaron, Bankert, Richard B., Matsuzaki, Junko, Koya, Richard C., Blom, Anna M., McLeish, Kenneth R., Qu, Jun, Ram, Sanjay, Moysich, Kirsten B., Abrams, Scott I., Odunsi, Kunle, Zsiros, Emese, Segal, Brahm H.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2019
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6483507/
https://ncbi.nlm.nih.gov/pubmed/30730851
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.122311
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