Enhanced detection of circulating tumor DNA by fragment size analysis

Existing methods to improve detection of circulating tumor DNA (ctDNA) have focused on sensitivity for detecting genomic alterations but have rarely considered the biological properties of plasma cell-free DNA (cfDNA). We hypothesized that differences in fragment lengths of circulating DNA could be...

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Detalhes bibliográficos
Publicado no:Sci Transl Med
Principais autores: Mouliere, Florent, Chandrananda, Dineika, Piskorz, Anna M., Moore, Elizabeth K., Morris, James, Ahlborn, Lise Barlebo, Mair, Richard, Goranova, Teodora, Marass, Francesco, Heider, Katrin, Wan, Jonathan C. M., Supernat, Anna, Hudecova, Irena, Gounaris, Ioannis, Ros, Susana, Jimenez-Linan, Mercedes, Garcia-Corbacho, Javier, Patel, Keval, Østrup, Olga, Murphy, Suzanne, Eldridge, Matthew D., Gale, Davina, Stewart, Grant D., Burge, Johanna, Cooper, Wendy N., van der Heijden, Michiel S., Massie, Charles E., Watts, Colin, Corrie, Pippa, Pacey, Simon, Brindle, Kevin, Baird, Richard D., Mau-Sørensen, Morten, Parkinson, Christine A., Smith, Christopher G., Brenton, James D., Rosenfeld, Nitzan
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6483061/
https://ncbi.nlm.nih.gov/pubmed/30404863
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.aat4921
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