Detection of cell‐free DNA fragmentation and copy number alterations in cerebrospinal fluid from glioma patients

Glioma is difficult to detect or characterize using current liquid biopsy approaches. Detection of cell‐free tumor DNA (cftDNA) in cerebrospinal fluid (CSF) has been proposed as an alternative to detection in plasma. We used shallow whole‐genome sequencing (sWGS, at a coverage of < 0.4×) of cell‐...

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Udgivet i:EMBO Mol Med
Main Authors: Mouliere, Florent, Mair, Richard, Chandrananda, Dineika, Marass, Francesco, Smith, Christopher G, Su, Jing, Morris, James, Watts, Colin, Brindle, Kevin M, Rosenfeld, Nitzan
Format: Artigo
Sprog:Inglês
Udgivet: John Wiley and Sons Inc. 2018
Fag:
Report
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6284385/
https://ncbi.nlm.nih.gov/pubmed/30401727
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/emmm.201809323
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