Detection of cell‐free DNA fragmentation and copy number alterations in cerebrospinal fluid from glioma patients

Glioma is difficult to detect or characterize using current liquid biopsy approaches. Detection of cell‐free tumor DNA (cftDNA) in cerebrospinal fluid (CSF) has been proposed as an alternative to detection in plasma. We used shallow whole‐genome sequencing (sWGS, at a coverage of < 0.4×) of cell‐...

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Publicado en:EMBO Mol Med
Main Authors: Mouliere, Florent, Mair, Richard, Chandrananda, Dineika, Marass, Francesco, Smith, Christopher G, Su, Jing, Morris, James, Watts, Colin, Brindle, Kevin M, Rosenfeld, Nitzan
Formato: Artigo
Idioma:Inglês
Publicado: John Wiley and Sons Inc. 2018
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6284385/
https://ncbi.nlm.nih.gov/pubmed/30401727
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/emmm.201809323
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