Sympathoexcitation in response to cardiac and pulmonary afferent stimulation of TRPA1 channels is attenuated in rats with chronic heart failure

Excessive sympathoexcitation characterizes the chronic heart failure (CHF) state. An exaggerated cardiac sympathetic afferent reflex (CSAR) contributes to this sympathoexcitation. Prior studies have demonstrated that the CSAR to capsaicin [transient receptor potential (TRP) vanilloid 1 agonist] is e...

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Udgivet i:Am J Physiol Heart Circ Physiol
Main Authors: Adam, Ryan J., Xia, Zhiqiu, Pravoverov, Kristina, Hong, Juan, Case, Adam J., Schultz, Harold D., Lisco, Steven J., Zucker, Irving H., Wang, Han-Jun
Format: Artigo
Sprog:Inglês
Udgivet: American Physiological Society 2019
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6483016/
https://ncbi.nlm.nih.gov/pubmed/30707612
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpheart.00696.2018
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