Different Munc18 proteins mediate baseline and stimulated airway mucin secretion

Airway mucin secretion is necessary for ciliary clearance of inhaled particles and pathogens but can be detrimental in pathologies such as asthma and cystic fibrosis. Exocytosis in mammals requires a Munc18 scaffolding protein, and airway secretory cells express all 3 Munc18 isoforms. Using conditio...

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Detalhes bibliográficos
Publicado no:JCI Insight
Main Authors: Jaramillo, Ana M., Piccotti, Lucia, Velasco, Walter V., Delgado, Anna Sofia Huerta, Azzegagh, Zoulikha, Chung, Felicity, Nazeer, Usman, Farooq, Junaid, Brenner, Josh, Parker-Thornburg, Jan, Scott, Brenton L., Evans, Christopher M., Adachi, Roberto, Burns, Alan R., Kreda, Silvia M., Tuvim, Michael J., Dickey, Burton F.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2019
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6483006/
https://ncbi.nlm.nih.gov/pubmed/30721150
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.124815
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