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Azabicyclic vinyl sulfones for residue-specific dual protein labelling
We have developed [2.2.1]azabicyclic vinyl sulfone reagents that simultaneously enable cysteine-selective protein modification and introduce a handle for further bioorthogonal ligation. The reaction is fast and selective for cysteine relative to other amino acids that have nucleophilic side-chains,...
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| Publicado no: | Chem Sci |
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| Main Authors: | , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Royal Society of Chemistry
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6482879/ https://ncbi.nlm.nih.gov/pubmed/31057781 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c9sc00125e |
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