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Deletion of leptin receptors in vagal afferent neurons disrupts estrogen signaling, body weight, food intake and hormonal controls of feeding in female mice

Deletion of the leptin receptor from vagal afferent neurons (VAN) using a conditional deletion (Nav1.8/LepR(fl/fl)) results in an obese phenotype with increased food intake and lack of exogenous cholecystokinin (CCK)-induced satiation in male mice. Female mice are partially protected from weight gai...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Am J Physiol Endocrinol Metab
Prif Awduron: Huang, Kuei-Pin, Ronveaux, Charlotte C., de Lartigue, Guillaume, Geary, Nori, Asarian, Lori, Raybould, Helen E.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Physiological Society 2019
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC6482667/
https://ncbi.nlm.nih.gov/pubmed/30753113
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpendo.00296.2018
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