Leptin Resistance in Vagal Afferent Neurons Inhibits Cholecystokinin Signaling and Satiation in Diet Induced Obese Rats

BACKGROUND AND AIMS: The gastrointestinal hormone cholecystokinin (CCK) plays an important role in regulating meal size and duration by activating CCK1 receptors on vagal afferent neurons (VAN). Leptin enhances CCK signaling in VAN via an early growth response 1 (EGR1) dependent pathway thereby incr...

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Autores principales: de Lartigue, Guillaume, Barbier de la Serre, Claire, Espero, Elvis, Lee, Jennifer, Raybould, Helen E.
Formato: Artigo
Lenguaje:Inglês
Publicado: Public Library of Science 2012
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Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3296757/
https://ncbi.nlm.nih.gov/pubmed/22412960
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0032967
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