Assessing Therapeutic Efficacy of MEK Inhibition in a KRAS(G12C)-Driven Mouse Model of Lung Cancers

PURPOSE: Despite the challenge to directly target mutant KRAS due to its high GTP affinity, some agents are under development against downstream signaling pathways, such as MEK inhibitors. However, it remains controversial whether MEK inhibitors can boost current chemotherapy in KRAS-mutant lung tum...

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Publicado no:Clin Cancer Res
Main Authors: Li, Shuai, Liu, Shengwu, Deng, Jiehui, Akbay, Esra A., Hai, Josephine, Ambrogio, Chiara, Zhang, Long, Zhou, Fangyu, Jenkins, Russell W., Adeegbe, Dennis O., Gao, Peng, Wang, Xiaoen, Paweletz, Cloud P., Herter-Sprie, Grit S., Chen, Ting, Gutiérrez-Quiceno, Laura, Zhang, Yanxi, Merlino, Ashley A., Quinn, Max M., Zeng, Yu, Yu, Xiaoting, Liu, Yuting, Fan, Lichao, Aguirre, Andrew J., Barbie, David A., Yi, Xianghua, Wong, Kwok-Kin
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6482448/
https://ncbi.nlm.nih.gov/pubmed/29945997
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-17-3438
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