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Rational cotargeting of HDAC6 and BET proteins yields synergistic antimyeloma activity
Inhibition of bromodomain and extra terminal (BET) protein family members, including BRD4, decreases the expression of c-MYC and other key oncogenic factors and also significantly induces histone deacetylase 6 (HDAC6) expression. On the basis of the role of HDAC6 in malignant pathogenesis, we hypoth...
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| Publicado no: | Blood Adv |
|---|---|
| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society of Hematology
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6482361/ https://ncbi.nlm.nih.gov/pubmed/31015208 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/bloodadvances.2018026484 |
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