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Identification of NMS-873, an allosteric and specific p97 inhibitor, as a broad antiviral against both influenza A and B viruses

Influenza virus infection causes substantial morbidity and mortality worldwide. The limited efficacy of oseltamivir in delayed treatment, coupled with the increasing incidences of oseltamivir-resistant strains, calls for next-generation of antiviral drugs. In this study, we discovered NMS-873, an al...

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Dettagli Bibliografici
Pubblicato in:Eur J Pharm Sci
Autori principali: Zhang, Jiantao, Hu, Yanmei, Hau, Raymond, Musharrafieh, Rami, Ma, Chunlong, Zhou, Xu, Chen, Yin, Wang, Jun
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2019
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6482079/
https://ncbi.nlm.nih.gov/pubmed/30930289
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejps.2019.03.020
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