The Tandem Duplicator Phenotype Is a Prevalent Genome-Wide Cancer Configuration Driven by Distinct Gene Mutations

The tandem duplicator phenotype (TDP) is a genome-wide instability configuration primarily observed in breast, ovarian, and endometrial carcinomas. Here, we stratify TDP tumors by classifying their tandem duplications (TDs) into three span intervals, with modal values of 11 kb, 231 kb, and 1.7 Mb, r...

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Detalhes bibliográficos
Publicado no:Cancer Cell
Main Authors: Menghi, Francesca, Barthel, Floris P., Yadav, Vinod, Tang, Ming, Ji, Bo, Tang, Zhonghui, Carter, Gregory W., Ruan, Yijun, Scully, Ralph, Verhaak, Roel G.W., Jonkers, Jos, Liu, Edison T.
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6481635/
https://ncbi.nlm.nih.gov/pubmed/30017478
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccell.2018.06.008
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