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Incorporating individual historical controls and aggregate treatment effect estimates into a Bayesian survival trial: a simulation study

BACKGROUND: Performing well-powered randomised controlled trials (RCTs) of new treatments for rare diseases is often infeasible. However, with the increasing availability of historical data, incorporating existing information into trials with small sample sizes is appealing in order to increase the...

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Veröffentlicht in:BMC Med Res Methodol
Hauptverfasser: Brard, Caroline, Hampson, Lisa V., Gaspar, Nathalie, Le Deley, Marie-Cécile, Le Teuff, Gwénaël
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2019
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6480797/
https://ncbi.nlm.nih.gov/pubmed/31018832
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12874-019-0714-z
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