AICAR Induces Apoptosis and Inhibits Migration and Invasion in Prostate Cancer Cells Through an AMPK/mTOR-Dependent Pathway

Current clinical challenges of prostate cancer management are to restrict tumor growth and prohibit metastasis. AICAR (5-aminoimidazole-4-carbox-amide-1-β-d-ribofuranoside), an AMP-activated protein kinase (AMPK) agonist, has demonstrated antitumor activities for several types of cancers. However, t...

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Pubblicato in:Int J Mol Sci
Autori principali: Su, Chia-Cheng, Hsieh, Kun-Lin, Liu, Po-Len, Yeh, Hsin-Chih, Huang, Shu-Pin, Fang, Shih-Hua, Cheng, Wei-Chung, Huang, Kuan-Hua, Chiu, Fang-Yen, Lin, I-Ling, Huang, Ming-Yii, Li, Chia-Yang
Natura: Artigo
Lingua:Inglês
Pubblicazione: MDPI 2019
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6480054/
https://ncbi.nlm.nih.gov/pubmed/30987073
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms20071647
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