The AMPK Agonist AICAR Inhibits TGF-β1 Induced Activation of Kidney Myofibroblasts

Activation of interstitial myofibroblasts and excessive production of extracellular matrix proteins are common pathways that contribute to chronic kidney disease. In a number of tissues, AMP-activated kinase (AMPK) activation has been shown to inhibit fibrosis. Here, we examined the inhibitory effec...

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Detalhes bibliográficos
Main Authors: Chen, Kuan-Hsing, Hsu, Hsiang-Hao, Lee, Cheng-Chia, Yen, Tzu-Hai, Ko, Yi-Ching, Yang, Chih-Wei, Hung, Cheng-Chieh
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4154690/
https://ncbi.nlm.nih.gov/pubmed/25188319
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0106554
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