PIM kinases facilitate lentiviral evasion from SAMHD1 restriction via Vpx phosphorylation

Lentiviruses have evolved to acquire an auxiliary protein Vpx to counteract the intrinsic host restriction factor SAMHD1. Although Vpx is phosphorylated, it remains unclear whether such phosphorylation indeed regulates its activity toward SAMHD1. Here we identify the PIM family of serine/threonine p...

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Publicat a:Nat Commun
Autors principals: Miyakawa, Kei, Matsunaga, Satoko, Yokoyama, Masaru, Nomaguchi, Masako, Kimura, Yayoi, Nishi, Mayuko, Kimura, Hirokazu, Sato, Hironori, Hirano, Hisashi, Tamura, Tomohiko, Akari, Hirofumi, Miura, Tomoyuki, Adachi, Akio, Sawasaki, Tatsuya, Yamamoto, Naoki, Ryo, Akihide
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2019
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6479052/
https://ncbi.nlm.nih.gov/pubmed/31015445
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-09867-7
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