PIM kinases facilitate lentiviral evasion from SAMHD1 restriction via Vpx phosphorylation

Lentiviruses have evolved to acquire an auxiliary protein Vpx to counteract the intrinsic host restriction factor SAMHD1. Although Vpx is phosphorylated, it remains unclear whether such phosphorylation indeed regulates its activity toward SAMHD1. Here we identify the PIM family of serine/threonine p...

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Udgivet i:Nat Commun
Main Authors: Miyakawa, Kei, Matsunaga, Satoko, Yokoyama, Masaru, Nomaguchi, Masako, Kimura, Yayoi, Nishi, Mayuko, Kimura, Hirokazu, Sato, Hironori, Hirano, Hisashi, Tamura, Tomohiko, Akari, Hirofumi, Miura, Tomoyuki, Adachi, Akio, Sawasaki, Tatsuya, Yamamoto, Naoki, Ryo, Akihide
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6479052/
https://ncbi.nlm.nih.gov/pubmed/31015445
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-09867-7
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