A small molecule promotes cartilage extracellular matrix generation and inhibits osteoarthritis development

Degradation of extracellular matrix (ECM) underlies loss of cartilage tissue in osteoarthritis, a common disease for which no effective disease-modifying therapy currently exists. Here we describe BNTA, a small molecule with ECM modulatory properties. BNTA promotes generation of ECM components in cu...

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Pubblicato in:Nat Commun
Autori principali: Shi, Yuanyuan, Hu, Xiaoqing, Cheng, Jin, Zhang, Xin, Zhao, Fengyuan, Shi, Weili, Ren, Bo, Yu, Huilei, Yang, Peng, Li, Zong, Liu, Qiang, Liu, Zhenlong, Duan, Xiaoning, Fu, Xin, Zhang, Jiying, Wang, Jianquan, Ao, Yingfang
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2019
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6478911/
https://ncbi.nlm.nih.gov/pubmed/31015473
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-09839-x
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