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Vps11 and Vps18 of Vps-C membrane traffic complexes are E3 ubiquitin ligases and fine-tune signalling

In response to extracellular signals, many signalling proteins associated with the plasma membrane are sorted into endosomes. This involves endosomal fusion, which depends on the complexes HOPS and CORVET. Whether and how their subunits themselves modulate signal transduction is unknown. We show tha...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Segala, Gregory, Bennesch, Marcela A., Ghahhari, Nastaran Mohammadi, Pandey, Deo Prakash, Echeverria, Pablo C., Karch, François, Maeda, Robert K., Picard, Didier
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6478910/
https://ncbi.nlm.nih.gov/pubmed/31015428
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-09800-y
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