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A DNMT3A PWWP mutation leads to methylation of bivalent chromatin and growth retardation in mice
DNA methyltransferases (DNMTs) deposit DNA methylation, which regulates gene expression and is essential for mammalian development. Histone post-translational modifications modulate the recruitment and activity of DNMTs. The PWWP domains of DNMT3A and DNMT3B are posited to interact with histone 3 ly...
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| Udgivet i: | Nat Commun |
|---|---|
| Main Authors: | , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Nature Publishing Group UK
2019
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6478690/ https://ncbi.nlm.nih.gov/pubmed/31015495 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-09713-w |
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