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Structural basis of cooling agent and lipid sensing by the cold-activated TRPM8 channel
Transient receptor potential melastatin member 8 (TRPM8) is a calcium ion (Ca(2+))-permeable cation channel that serves as the primary cold and menthol sensor in humans. Activation of TRPM8 by cooling compounds relies on allosteric actions of agonist and membrane lipid phosphatidylinositol 4,5-bisph...
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| 發表在: | Science |
|---|---|
| Main Authors: | , , , , , |
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
2019
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6478609/ https://ncbi.nlm.nih.gov/pubmed/30733385 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aav9334 |
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