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The Immunosuppressant Macrolide Tacrolimus Activates Cold-Sensing TRPM8 Channels
TRPM8 is a polymodal, nonselective cation channel activated by cold temperature and cooling agents that plays a critical role in the detection of environmental cold. We found that TRPM8 is a pharmacological target of tacrolimus (FK506), a macrolide immunosuppressant with several clinical uses, inclu...
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| Veröffentlicht in: | J Neurosci |
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| Hauptverfasser: | , , , , , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Society for Neuroscience
2019
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6363935/ https://ncbi.nlm.nih.gov/pubmed/30545944 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.1726-18.2018 |
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