The Immunosuppressant Macrolide Tacrolimus Activates Cold-Sensing TRPM8 Channels

TRPM8 is a polymodal, nonselective cation channel activated by cold temperature and cooling agents that plays a critical role in the detection of environmental cold. We found that TRPM8 is a pharmacological target of tacrolimus (FK506), a macrolide immunosuppressant with several clinical uses, inclu...

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Bibliografiske detaljer
Udgivet i:J Neurosci
Main Authors: Arcas, José Miguel, González, Alejandro, Gers-Barlag, Katharina, González-González, Omar, Bech, Federico, Demirkhanyan, Lusine, Zakharian, Eleonora, Belmonte, Carlos, Gomis, Ana, Viana, Félix
Format: Artigo
Sprog:Inglês
Udgivet: Society for Neuroscience 2019
Fag:
Research Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6363935/
https://ncbi.nlm.nih.gov/pubmed/30545944
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.1726-18.2018
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