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KCNQ1 rescues TMC1 plasma membrane expression but not mechanosensitive channel activity
Transmembrane channel-like protein isoform 1 (TMC1) is essential for generation of mechano-electrical transducer currents in hair cells of the inner ear. TMC1 disruption causes hair cell degeneration and deafness in mice and humans. Although thought to be expressed at the cell surface in vivo, TMC1...
Gorde:
Argitaratua izan da: | J Cell Physiol |
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Egile Nagusiak: | , , , , |
Formatua: | Artigo |
Hizkuntza: | Inglês |
Argitaratua: |
2019
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Gaiak: | |
Sarrera elektronikoa: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6478532/ https://ncbi.nlm.nih.gov/pubmed/30613966 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jcp.28013 |
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