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Protein Kinase C downregulates I(Ks) by stimulating KCNQ1-KCNE1 potassium channel endocytosis
BACKGROUND: The slow-activating cardiac repolarization K(+) current (I(Ks)), generated by the KCNQ1-KCNE1 potassium channel complex, is controlled via sympathetic and parasympathetic regulation in vivo. Inherited KCNQ1 and KCNE1 mutations predispose to ventricular fibrillation and sudden death, ofte...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3183296/ https://ncbi.nlm.nih.gov/pubmed/21699843 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.hrthm.2011.04.034 |
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