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Genetic dissection reveals unexpected influence of β subunits on KCNQ1 K(+) channel polarized trafficking in vivo
Targeted deletion of the Kcne2 potassium channel β subunit gene ablates gastric acid secretion and predisposes to gastric neoplasia in mice. Here, we discovered that Kcne2 deletion basolaterally reroutes the Kcnq1 α subunit in vivo in parietal cells (PCs), in which the normally apical location of th...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Federation of American Societies for Experimental Biology
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3023397/ https://ncbi.nlm.nih.gov/pubmed/21084694 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.10-173682 |
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