Genetic dissection reveals unexpected influence of β subunits on KCNQ1 K(+) channel polarized trafficking in vivo

Targeted deletion of the Kcne2 potassium channel β subunit gene ablates gastric acid secretion and predisposes to gastric neoplasia in mice. Here, we discovered that Kcne2 deletion basolaterally reroutes the Kcnq1 α subunit in vivo in parietal cells (PCs), in which the normally apical location of th...

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Detaylı Bibliyografya
Asıl Yazarlar: Roepke, Torsten K., King, Elizabeth C., Purtell, Kerry, Kanda, Vikram A., Lerner, Daniel J., Abbott, Geoffrey W.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Federation of American Societies for Experimental Biology 2011
Konular:
Research Communications
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3023397/
https://ncbi.nlm.nih.gov/pubmed/21084694
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.10-173682
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