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DBC1 Regulates p53 Stability via Inhibition of CBP-Dependent p53 Polyubiquitination
The control of p53 protein stability is critical to its tumor suppressor functions. The CREB binding protein (CBP) transcriptional co-activator co-operates with MDM2 to maintain normally low physiological p53 levels in cells via exclusively cytoplasmic E4 polyubiquitination activity. Using mass spec...
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| Publicado no: | Cell Rep |
|---|---|
| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6478392/ https://ncbi.nlm.nih.gov/pubmed/30893604 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2019.02.076 |
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