Glucagon Receptor Antagonist–Stimulated α-Cell Proliferation Is Severely Restricted With Advanced Age

Glucagon-containing α-cells potently regulate glucose homeostasis, but the developmental biology of α-cells in adults remains poorly understood. Although glucagon receptor antagonists (GRAs) have great potential as antidiabetic therapies, murine and human studies have raised concerns that GRAs might...

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Vydáno v:Diabetes
Hlavní autoři: Lam, Carol J., Rankin, Matthew M., King, Kourtney B., Wang, Melinda C., Shook, Brian C., Kushner, Jake A.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Diabetes Association 2019
Témata:
Islet Studies
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6477910/
https://ncbi.nlm.nih.gov/pubmed/30833466
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db18-1293
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