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Combining directed evolution of pathway enzymes and dynamic pathway regulation using a quorum-sensing circuit to improve the production of 4-hydroxyphenylacetic acid in Escherichia coli

BACKGROUND: 4-Hydroxyphenylacetic acid (4HPAA) is an important building block for synthesizing drugs, agrochemicals, biochemicals, etc. 4HPAA is currently produced exclusively via petrochemical processes and the process is environmentally unfriendly and unsustainable. Microbial cell factory would be...

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Foilsithe in:Biotechnol Biofuels
Main Authors: Shen, Yu-Ping, Fong, Lai San, Yan, Zhi-Bo, Liu, Jian-Zhong
Formáid: Artigo
Teanga:Inglês
Foilsithe: BioMed Central 2019
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6477704/
https://ncbi.nlm.nih.gov/pubmed/31044007
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13068-019-1438-3
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