Combining directed evolution of pathway enzymes and dynamic pathway regulation using a quorum-sensing circuit to improve the production of 4-hydroxyphenylacetic acid in Escherichia coli

BACKGROUND: 4-Hydroxyphenylacetic acid (4HPAA) is an important building block for synthesizing drugs, agrochemicals, biochemicals, etc. 4HPAA is currently produced exclusively via petrochemical processes and the process is environmentally unfriendly and unsustainable. Microbial cell factory would be...

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Bibliografiske detaljer
Udgivet i:Biotechnol Biofuels
Main Authors: Shen, Yu-Ping, Fong, Lai San, Yan, Zhi-Bo, Liu, Jian-Zhong
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2019
Fag:
Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6477704/
https://ncbi.nlm.nih.gov/pubmed/31044007
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13068-019-1438-3
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