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ATP and NADPH engineering of Escherichia coli to improve the production of 4-hydroxyphenylacetic acid using CRISPRi

BACKGROUND: 4-Hydroxyphenylacetic acid (4HPAA) is an important raw material for the synthesis of drugs, pesticides and biochemicals. Microbial biotechnology would be an attractive approach for 4HPAA production, and cofactors play an important role in biosynthesis. RESULTS: We developed a novel strat...

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Detalhes bibliográficos
Publicado no:Biotechnol Biofuels
Main Authors: Shen, Yu-Ping, Liao, Yu-Ling, Lu, Qian, He, Xin, Yan, Zhi-Bo, Liu, Jian-Zhong
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2021
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8056492/
https://ncbi.nlm.nih.gov/pubmed/33879249
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13068-021-01954-6
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