Combining directed evolution of pathway enzymes and dynamic pathway regulation using a quorum-sensing circuit to improve the production of 4-hydroxyphenylacetic acid in Escherichia coli

BACKGROUND: 4-Hydroxyphenylacetic acid (4HPAA) is an important building block for synthesizing drugs, agrochemicals, biochemicals, etc. 4HPAA is currently produced exclusively via petrochemical processes and the process is environmentally unfriendly and unsustainable. Microbial cell factory would be...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:Biotechnol Biofuels
Päätekijät: Shen, Yu-Ping, Fong, Lai San, Yan, Zhi-Bo, Liu, Jian-Zhong
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: BioMed Central 2019
Aiheet:
Research
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC6477704/
https://ncbi.nlm.nih.gov/pubmed/31044007
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13068-019-1438-3
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